Prof. Nixdorff has been actively involved in clinical research of echocardiographic techniques in the context of chronic coronary syndrome, in addition to his internal cardiology residency training. In addition to chronic studies of the long-term course of myocardial infarction, he was involved in the development of stress echocardiography and tissue Doppler echocardiography in the 1990s, which was included in his post-doctoral thesis at the Johannes Gutenberg University in Mainz. During his time as a senior physician at the Friedrich-Alexander-University Erlangen-Nuremberg (FAU), this research was placed in the broader context of other imaging methods such as magnetic resonance and computer tomography. In the course of this work, an interest in early detection arose, which took its place in preventive medicine. Clinical algorithms were consistently established, which Nixdorff applies in practice and in the European Prevention Center (EPC), which he founded. This serves the benefit of his patients beyond cardiological diagnostics and therapy in the prevention of disease.